TORONTO - Chris Sale struck out 13 over eight shutout innings, Mookie Betts hit a 3-run double in the 10th and the Boston Red Sox beat the struggling Toronto Blue Jays 4-1 on Thursday.
At 3-12, Toronto is off to the worst start in team history and has lost its first five series for the first time.
Sandy Leon drew a 1-out walk from Jason Grilli (0-2) in the 10th, and Brock Holt singled to stop an 0-for-12 slide. Andrew Benintendi walked with two outs, and Betts pulled a 2-0 fastball down the left-field line.
Mitch Moreland hit a 2-out double in the ninth off Roberto Osuna and scored on Xander Bogaerts' single, but Kendrys Morales homered against Craig Kimbrel (1-0) leading off the bottom half, the eighth time Morales has tied a game or given his team a lead with a homer from the ninth inning on.
MINNEAPOLIS - Trevor Bauer struck out seven in 6 1/3 innings and Carlos Santana had two doubles and two RBI to lead the Cleveland Indians over the Minnesota Twins 6-2.
Bauer (1-2) gave up two runs, three hits and three walks. Andrew Miller pitched 1 1/3 innings of scoreless relief as the Indians took all three games.
ST. PETERSBURG, Fla. - Steven Souza Jr. came within a single of hitting for the cycle, Erasmo Ramirez and two relievers combined on a five-hitter, and the Tampa Bay Rays beat Detroit 8-1 for a 3-game sweep of the Tigers.
Souza doubled in the first, hit a 2-run triple in the second and added a solo homer in the eighth.
HOUSTON - Carlos Beltran hit his first home run this season and Jake Marisnick also homered to help the Houston Astros to a 2-1 win over the Los Angeles Angels.
Beltran's shot came with one out and the first inning off Matt Shoemaker (0-1), and Marisnick's second homer this season made it 2-0 in the fifth.
ATLANTA - Bryce Harper had two homers, including a grand slam, among four hits and the Washington Nationals overwhelmed Julio Teheran and the Atlanta Braves 14-4 on Wednesday night.
Harper drove in five runs. His third-inning grand slam just cleared the reach of leaping Braves center fielder Ender Inciarte. Harper's seven career homers off Teheran are his most against any pitcher.
Ryan Zimmerman added an eighth-inning grand slam off Ian Krol, sending some Braves fans for the exits at new SunTrust Park. The Nationals had 20 hits.
Washington's Joe Ross (1-0) allowed three runs on six hits in seven innings in his 2017 debut.
Teheran (1-1) allowed seven runs on seven hits in four innings.